ABSTRACT
@#Trigeminal neuralgia can be a manifestation of contralateral cerebellopontine angle tumor. We report here a 34 year old female patient who presented with right sided facial pain in first and second divison of right trigeminal nerve but her blink reflex was abnormal on the left side. Her brain MRI revealed a left cerebellopontine angle tumor displacing the pons as well as the basilar artery. The distortion and displacement of brainstem and the basilar artery contribute to the genesis of the trigeminal neuralgia contralaterally
ABSTRACT
A simple, reliable, rapid, precise, sensitive, rugged and validated RP-HPLC method has been developed to determine Metoprolol succinate and Lacidipine in synthetic mixture form. Chromatographic separation achieved isocratically on Prontosil C18 column [5micro m, 250mm × 4.60mm] and acetonitrile: 20mM Phosphate buffer [pH 3.6] in the ratio of 60:40 [v/v] as the mobile phase, at a flow rate of 1 mL/min. Detection was carried out at 278 nm. The mean retention times for metoprolol succinate and lacidipine was found to be 5.25+/-0.5 and 6.72+/-0.5 min, respectively. No interference was found by the excipients in the synthetic mixture. Linearity for metoprolol succinate and lacidipine was in the range of 5-25micro g/mL and 4-20micro g/mL, respectively. The mean recoveries obtained for metoprolol succinate and lacidipine were 100.03 and 99.67 % respectively and RSD was less than 2. The correlation coefficients for all components are close to 1. The proposed method was validated in terms of linearity, range, accuracy, precision, specificity, robustness and the method is successfully applies to the estimation of metoprolol succinate and lacidipine in bulk and in a synthetic mixture
ABSTRACT
A novel, eco friendly, accurate, sensitive, economic and safe spectrophotometric method was developed by application of mixed hydrotropy using 2 M sodium acetate, 8 M urea, 2 M niacinamide and 2 M sodium benzoate solution [25:25:25:25% V/V] as hydrotropic agent, for the solubalizing of poorly water-soluble Furazolidone [FZ] [solubility:- 3.64e-01 mg/mL in water]. There were more than 32 times enhancements in the solubility of FZ were found in mixed hydrotropic solution as compared to solubilities in distilled water. FZ shows maximum absorbance at 360 nm where sodium acetate, urea, niacinamide, sodium benzoate and other tablets excipients did not show any absorbance above 300 nm, and thus no interference in the estimation was seen. FZ was obeyed Beer's law in the concentration range of 10 to 50 micro g/ml r[2]0.9992] in mixed hydrotropic solvent with mean recovery ranging from 97.32% to 98.9%. Proposed method is new, simple, economic, safe, rapid, accurate and reproducible and was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values